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KMID : 1234920090090020011
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Journal of Korean Oriental Association for Study of Obesity
2009 Volume.9 No. 2 p.11 ~ p.19
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A Study on the Acute Toxicity of Fermented Bangpungtongsung-san(Fangfengtongsheng-san) Extract in ICR Mice
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Lee Ji-Hye
Lee Jae-Hoon
Um Young-Ran
Ma Jin-Yeul
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Abstract
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Objectives: In this study, we investigated the acute toxicity and safety about fermented Bangpungtongsung-san(Fangfengtongsheng-san) extract.
Methods: To evaluate the acute toxity and safety, fermented Bangpungtongsung-san (Fangfengtongsheng-san) at the respective doses of 0(control group), 1250, 2500 and 5000 mg/kg were orally treated to 20 male and 20 female mice. After single administration, we observed survival rates, general toxicity, changes of body weight and autopsy.
Results: Compared with the control group, we could not find any toxic alteration in all treated groups (1250, 2500 and 5000 mg/kg).
Conclusions: of fermented Bangpungtongsung-san(Fangfengtongsheng-san) extract might be over 5000 mg/kg and it is very safe to ICR mice.
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KEYWORD
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Bangpungtongsung-san(Fangfengtongsheng-san), Fermentation, Acute toxicity, Safety,
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